4-Ethynyl-L-phenylalanine
| Chemical Name | 4-Ethynyl-L-phenylalanine |
|---|---|
| CAS Number | 278605-15-5 |
| Molecular Formula | C11H11NO2 |
| Molecular Weight | 189.21 |
Introduction of 278605-15-5 :
4-Ethynyl-L-phenylalanine is a selective, reversible, potent and competitive inhibitor of tryptophan hydroxylase (TPH). 4-Ethynyl-L-phenylalanine is a competitive inhibitor with regard to the substrate tryptophan, with a Ki of 32.6 μM. 4-Ethynyl-L-phenylalanine selectively and reversibly inhibits the biosynthesis of serotonin[1]. IC50 & Target: Ki: 32.6 μM (TPH)[1] In Vivo: 4-Ethynyl-L-phenylalanine (30 mg/kg; i.p.) decreases in 5-HT and 5-HIAA levels in the rat midbrain but not in tissue[1].
4-Ethynyl-L-phenylalanine is not inhibiting the aromatic amino acid decarboxylase[1].
4-Ethynyl-L-phenylalanine has a low affinity for various recombinant 5-HT receptors[1].
| Purity | NLT 98% |
|---|---|
| Storage | at 20ºC 2 years |
*The above information is for reference only.