PKI-166
| Chemical Name | PKI-166 |
|---|---|
| CAS Number | 187724-61-4 |
| MDL Number | MFCD09970842 |
| Molecular Formula | C20H18N4O |
| Molecular Weight | 330.38 |
Introduction of 187724-61-4 :
PKI-166 is a potent, selective and orally bioavailable EGFR tyrosine kinase inhibitor, with an IC50 of 0.7 nM[1]. IC50 & Target: IC50: 0.7 nM (EGFR tyrosine kinase)[1] In Vitro: Pretreatment with PKI-166 (0–0.5 μM; 1 hour) inhibits EGFR autophosphorylation in human pancreatic cancer cells[1].
PKI-166 (0.03μ M; 6 days) enhanced the cytotoxicity mediated by gemcitabine[1].
In Vivo: PKI-166 (100 mg/kg; p.o.; daily; day 7-day 35 after xenograft) inhibits of pancreatic cancer growth[1].
| Purity | NLT 98% |
|---|---|
| Storage | at 20ºC 2 years |
*The above information is for reference only.