PKI-166
| 화학 이름 | PKI-166 |
|---|---|
| 화학 이름 | PKI-166 |
| CAS 번호 | 187724-61-4 |
| MDL 번호 | MFCD09970842 |
| 분자식 | C20H18N4O |
| 분자 무게 | 330.38 |
Introduction of 187724-61-4 :
PKI-166 is a potent, selective and orally bioavailable EGFR tyrosine kinase inhibitor, with an IC50 of 0.7 nM[1]. IC50 & Target: IC50: 0.7 nM (EGFR tyrosine kinase)[1] In Vitro: Pretreatment with PKI-166 (0–0.5 μM; 1 hour) inhibits EGFR autophosphorylation in human pancreatic cancer cells[1].
PKI-166 (0.03μ M; 6 days) enhanced the cytotoxicity mediated by gemcitabine[1].
In Vivo: PKI-166 (100 mg/kg; p.o.; daily; day 7-day 35 after xenograft) inhibits of pancreatic cancer growth[1].
| 청정 | NLT 98% |
|---|---|
| 저장 | at 20ºC 2 years |
*위의 정보는 참고 용입니다.