Chemical Name |
IRL 2500 |
CAS Number |
169545-27-1 |
MDL Number |
MFCD00948945 |
Molecular Formula |
C36H35N3O4 |
Molecular Weight |
573.68 |
Introduction of 169545-27-1 :
IRL 2500 is a potent Endothelin receptor antagonist. IRL 2500 shows IC50 values of 1.3 and 94 nM for ETB and ETA receptors, respectively. IRL 2500 inhibits ETB receptor-mediated blood pressure increase and renal vascular resistance in rats in vivo[1]. In Vivo: IRL 2500 (intravenous injection;10 mg/kg) inhibits the initial transient decrease in mean arterial pressure (MAP) induced by the ETB-selective agonist IRL 1620 in rats, IRL 2500 also attenuates the IRL 1620-mediated increase in renal vascular resistance (RVR) in the anesthetized rat[1].
IRL 2500 (intravenous injection;10 mg/kg) pre-reatment significantly reduces the initial vasodepressor response to endothelin-1 (ET-1) and IRL 1620, however, it is not alters the secondary and sustained pressor response to these agonists[2].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.