CAS No. 169545-27-1, IRL 2500

IRL 2500

NLT 98%
169545-27-1
DY530831
IRL 2500
C36H35N3O4
573.68

견적 요청

화학 이름 IRL 2500
화학 이름 IRL 2500
CAS 번호 169545-27-1
MDL 번호 MFCD00948945
분자식 C36H35N3O4
분자 무게 573.68
Introduction of 169545-27-1 :

IRL 2500 is a potent Endothelin receptor antagonist. IRL 2500 shows IC50 values of 1.3 and 94 nM for ETB and ETA receptors, respectively. IRL 2500 inhibits ETB receptor-mediated blood pressure increase and renal vascular resistance in rats in vivo[1]. In Vivo: IRL 2500 (intravenous injection;10 mg/kg) inhibits the initial transient decrease in mean arterial pressure (MAP) induced by the ETB-selective agonist IRL 1620 in rats, IRL 2500 also attenuates the IRL 1620-mediated increase in renal vascular resistance (RVR) in the anesthetized rat[1].
IRL 2500 (intravenous injection;10 mg/kg) pre-reatment significantly reduces the initial vasodepressor response to endothelin-1 (ET-1) and IRL 1620, however, it is not alters the secondary and sustained pressor response to these agonists[2].

청정 NLT 98%
저장 at 20ºC 2 years
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견적 요청

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