Chemical Name |
Crosstide |
CAS Number |
171783-05-4 |
MDL Number |
MFCD03787963 |
Molecular Formula |
C48H77N17O17 |
Molecular Weight |
1164.23 |
Introduction of 171783-05-4 :
Crosstide is a peptide analog of glycogen synthase kinase α/β fusion protein sequence which is a substrate for Akt. In Vitro: 16HBE14o− cells exposed to RV39 demonstrate a crosstide kinase activity in vitro. Serine phosphorylation of crosstide is confirmed by immunoblotting, and phosphorylation is blocked by PP2 but not by PP3[1]. The wildtype GST-AKT2 shows significant phosphoryl transferase activity towards crosstide, reaching an initial velocity of 16 pmol phosphate/min/μg enzyme. The mutant GST-AKT2T/E,S/D displayed an initial velocity of 85 pmol phosphate/min/μg kinase for phosphorylation of Crosstide, corresponding to a 5-fold increase compared to the wildtype enzyme[2].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.