TAPI-1
| Chemical Name | TAPI-1 |
|---|---|
| CAS Number | 163847-77-6 |
| MDL Number | MFCD02684280 |
| Molecular Formula | C26H37N5O5 |
| Molecular Weight | 499.60 |
Introduction of 163847-77-6 :
TAPI-1 is a TACE (ADAM17) inhibitor and blocks the shedding of several cell surface proteins[1]. TAPI-1 is also a metalloproteinase (MMP) inhibitor[2]. IC50 & Target: TACE (ADAM17)[1], MMP[2] In Vitro: TAPI-1 (1 µM for 30 min) increases cell viability in LPS-treated HK-2 cells[1].
TAPI-1 attenuates oxidative stress and inflammatory cytokines[1]
LPS treatment significantly induces renal IL-6 and TNFα mRNA expression, while these changes is attenuated with TAPI-1 pretreatment in LPS-treated HK-2 cells[1].
| Purity | NLT 98% |
|---|---|
| Storage | at 20ºC 2 years |
*The above information is for reference only.