CAS No. 163521-08-2, Vilazodone (Hydrochloride)

Vilazodone (Hydrochloride)

NLT 98%
EMD 68843 (Hydrochloride);SB659746A (Hydrochloride)

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Chemical Name Vilazodone (Hydrochloride)
CAS Number 163521-08-2
MDL Number MFCD09838919
Molecular Formula C26H27N5O2
Molecular Weight 441.52
Synonyms EMD 68843 (Hydrochloride);SB659746A (Hydrochloride)
Introduction of 163521-08-2 :

Vilazodone Hydrochloride (EMD 68843 Hydrochloride) is a serotonin transporter (SER) inhibitor and 5-HT1A receptor partial agonist. IC50 & Target: SER; 5-HT1A[1]. In Vivo: Administration of 5-HT1A receptor agonists produce a characteristic behavioral syndrome that includes changes in posture, hind limb reduction, head weaving, tremors, forepaw treading, and straub tail. In the rat ultrasonic vocalizations test, stress-induced vocalizations are inhibited by Vilazodone Hydrochloride (EMD 68843 Hydrochloride) (55 mg/kg po) at 120 and 210 min post dose. Vilazodone Hydrochloride (EMD 68843 Hydrochloride) (20-40 mg/kg ip), administered acutely or prophylactically (1 week prior to behavioral testing), attenuated stress induces potentiated startle but has no effect on stress potentiated anxiety response in the elevated plus maze. Interestingly, a lower dose of 10 mg/kg of Vilazodone Hydrochloride (EMD 68843 Hydrochloride) has the opposite effect in the startle response, indicating a somewhat unexplained bidirectional effect, and all doses produce a potentiation of the startle-induced stress response possibly suggestive of an anxiogenic-like response[1]. Vilazodone Hydrochloride (EMD 68843 Hydrochloride) also represents another option for the treatment of MDD[2].

Purity NLT 98%
Storage at 20ºC 2 years
*The above information is for reference only.

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