Chemical Name |
Cariporide |
CAS Number |
159138-80-4 |
MDL Number |
MFCD00864683 |
Molecular Formula |
C12H17N3O3S |
Molecular Weight |
283.35 |
Synonyms |
HOE-642 |
Introduction of 159138-80-4 :
Cariporide (HOE-642) is a selective Na+/H+ exchange inhibitor. In Vitro: Cariporide significantly suppresses markers of cell death, such as TUNEL positivity and caspase-3 cleavage, at 8 or 16 hours. Cariporide remarkably suppresses cytosolic Na+ and Ca2+ accumulation. Cariporide prevents mitochondrial membrane potential loss induced by H2+O2+[1]. Cariporide (HOE-642) ameliorates myocardial ischemia/reperfusion injury, by the well-established reduction of cytosolic Ca2+ in cardiac myocytes through inhibition of Na+/H+ exchange[2]. Cariporide (HOE-642), has inhibitory effects on the degranulation of human platelets, the formation of platelet–leukocyte-aggregates, and the activation of the GPIIb/IIIa receptor (PAC-1)[3]. In Vivo: Intravenous administration of cariporide significantly decreases brain Na+ uptake and reduces cerebral edema, brain swelling, and infarct volume[4].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.