CAS No. 138579-66-5, Galantide


NLT 98%

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Chemical Name Galantide
CAS Number 138579-66-5
MDL Number MFCD00144384
Molecular Formula C104H151N25O26S
Molecular Weight 2199.53
Introduction of 138579-66-5 :

Galantide is a reversible and non-specific galanin receptor antagonist. In Vitro: Galantide dose dependently (IC50=1.0 nM) antagonizes the galanin-mediated inhibition of the glucose-induced insulin secretion from mouse pancreatic islets. The antagonist is also found to displace 125I-monoiodo-[TyrZ6]galanin from membranes of the insulin producing Rin m 5F cells with an IC50 value of less than 0.1 nM[1]. In Vivo: Intracerebroventricular injection of galanin (5 micrograms/rat) inhibited sexual behavior in experienced male rats--without producing any other locomotor or behavioral deficit-, injection of the galanin antagonist, galantide, by the same route (1 or 2 micrograms/rat) stimulated sexual behavior (improving arousal, motivation and performance indexes) and antagonized the effect of galanin[2]. Galantide ameliorates mild acute pancreatitis (AP). Galantide significantly reduces AP-induced hyperenzymemia by 41–49%[3]. Galantide has been found to improve social memory in 'socialrecognition' test when i.c.v. administered at doses varying from 6-6000 nM[4].

Purity NLT 98%
Storage at 20ºC 2 years
*The above information is for reference only.

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