Dihydrexidine (hydrochloride)
| Chemical Name | Dihydrexidine (hydrochloride) |
|---|---|
| CAS Number | 137417-08-4 |
| MDL Number | MFCD01860859 |
| Molecular Formula | C17H18ClNO2 |
| Molecular Weight | 303.78 |
| Synonyms | DAR-0100 (hydrochloride) |
Introduction of 137417-08-4 :
Dihydrexidine hydrochloride (DAR-0100 hydrochloride) is a high potent, selective and full efficacy D1-like dopamine receptor (D1/D5) agonist, with an IC50 of 10 nM for D1 receptor. Dihydrexidine hydrochloride exhibits potent antiparkinsonian activity[1][2][3][4]. IC50 & Target: IC50: 10 nM (D1 dopamine receptor), D5 dopamine receptor, 660 nM (D2 dopamine receptor)[1] In Vivo: Dihydrexidine hydrochloride has poor oral bioavailability and a relatively short half-life of 1 to 2 h[3].
Dihydrexidine hydrochloride (3 mg/kg; i.p.) produces prominent dopamine D1 receptor agonist effects in vivo[4].
| Purity | NLT 98% |
|---|---|
| Storage | at 20ºC 2 years |
*The above information is for reference only.