Chemical Name |
Endothelin-2 (49-69), human |
CAS Number |
123562-20-9 |
MDL Number |
MFCD00133306 |
Molecular Formula |
C115H160N26O32S4 |
Molecular Weight |
2546.92 |
Synonyms |
Endothelin-2 (human, canine);Human endothelin-2 |
Introduction of 123562-20-9 :
Endothelin-2 (49-69), human (Endothelin-2 (human, canine)) is a 21-amino acid vasoactive peptide that binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB. In Vitro: At nanomolar concentrations, Endothelin-2 exhibits a strong and long-lasting vasoconstrictor activity characteristic of endothelin (EC50=0.52 nM)[1].
Endothelin-2 is a chemoattractant for macrophages and THP-1 monocytic cells, but not for freshly isolated monocytes. The chemotactic response to Endothelin-2 shows a typical bell-shaped response curve. Experiments with endothelin receptor antagonists shows that migration to Endothelin-2 is mediated via the ET-RB receptor. Endothelin-2 expression by tumors may modulate the behavior of macrophages such that activated cells accumulate in areas of hypoxia[2]. In Vivo: Two distinct phases of pressor effects are typically seen in response to Endothelin-2: the early phase immediately follows the depressor response and dominates during the next 3-10 min, whereas the late pressor effect develops 10-20 min after the injection and lasts >1 hr[1].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.