| Chemical Name |
D-erythro-Sphingosine |
| CAS Number |
123-78-4 |
| MDL Number |
MFCD00036751 |
| Molecular Formula |
C18H37NO2 |
| Molecular Weight |
299.49 |
| Synonyms |
Erythrosphingosine; erythro-C18-Sphingosine; trans-4-Sphingenine |
Introduction of 123-78-4 :
D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC50 of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator[1][2][3][4]. IC50 & Target: EC50: 8 μM (p32-kinase)[1]
PKC[2][3] In Vitro: A p32-sphingosine-activated protein kinase responds to low concentrations of D-erythro-Sphingosine with an initial activation observed at 2.5 μM and a peak activity at 10-20 μM. This kinase shows a modest specificity for D-erythro-Sphingosine over other sphingosine tereoisomers, and a preference for sphingosines over ihydrosphingosines[1]. D-erythro-Sphingosine inhibits protein kinase C in vitro[2]. D-erythro-Sphingosine has been shown to inhibit protein kinase C, which affects cell regulation and several signal transduction pathways, and exhibits antitumor promoter activities in various mammalian cells[3].
| Purity |
NLT 98% |
| Storage |
at 20ºC 2 years |
*The above information is for reference only.
