Chemical Name |
QL-IX-55 |
CAS Number |
1223002-54-7 |
MDL Number |
MFCD22417089 |
Molecular Formula |
C24H14F4N4O |
Molecular Weight |
450.39 |
Introduction of 1223002-54-7 :
QL-IX-55 is a selective ATP-competitive inhibitor of mTORC1/2 with IC50s of 50/50/10-50 nM for Human mTORC1/Yeast mTORC1/Yeast mTORC2, respectively. IC50 value: 50/50/10-50 nM (Human mTORC1/Yeast mTORC1/Yeast mTORC2) Target: mTORC1/2 The functional target of QL-IX-55 is the ATP-binding site of TOR2 as evidenced by the discovery of resistant alleles of TOR2 through rational design and unbiased selection strategies. QL-IX-55 is capable of potently inhibiting both TOR complex 1 and 2 (TORC1 and TORC2) as demonstrated by biochem. IP kinase assays (IC50 <50 nM) and cellular assays for inhibition of substrate YPK1 phosphorylation. In contrast to rapamycin, QL-IX-55 is capable of inhibiting TORC2-dependent transcription, which suggests that this compd. will be a powerful probe to dissect the Tor2/TORC2-related signaling pathway in yeast.
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.