Methyl Salicylate (Wintergreen oil) is a topical analgesic and anti-inflammatory agent. Also used as a pesticide, a denaturant, a fragrance ingredient, and a flavoring agent in food and tobacco products^[1]. A systemic acquired resistance (SAR) signal in tobacco^[2]. A topical nonsteroidal anti-inflammatory drug (NSAID). Methyl salicylate lactoside is a COX inhibitor^[4]. In Vitro: Methyl Salicylate is a systemic acquired resistance signal in tobacco. It (0-1 mg/L) esterases activity of salicylic acid–binding protein 2 (SABP2), which converts MeSA into salicylic acid (SA), is required for SAR signal perception in systemic tissue^[2].