Chemical Name |
Oxyphenisatin acetate |
CAS Number |
115-33-3 |
MDL Number |
MFCD00022793 |
Molecular Formula |
C24H19NO5 |
Molecular Weight |
401.41 |
Introduction of 115-33-3 :
Oxyphenisatin acetate, the pro-drug of oxyphenisatin, is used to be a laxative. In Vitro: Oxyphenisatin acetate inhibits the growth of the breast cancer cell lines MCF7, T47D, HS578T, and MDA-MB-468. In the estrogen receptor (ER) positive MCF7 and T47D cells, oxyphenisatin acetate induces TNFα expression and TNFR1 degradation, indicating autocrine receptor-mediated apoptosis in these lines. Ten micromoles per liter Oxyphenisatin acetate treatment results in autophagy and mitochondrial dysfunction[1]. In Vivo: Oxyphenisatin acetate (300 mg/kg, i.p.) delivers intraperitoneally inhibited tumor growth, accompanied by phosphorylation of eIF2α and degradation of TNFR1 in an MCF7 xenograft model[1].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.