Chemical Name |
Ascomycin |
CAS Number |
104987-12-4 |
MDL Number |
MFCD06198665 |
Molecular Formula |
C43H69NO12 |
Molecular Weight |
792.01 |
Synonyms |
Immunomycin;FR-900520;FK520 |
Introduction of 104987-12-4 :
Ascomycin(Immunomycin, FR-900520, FK520) is an ethyl analog of tacrolimus (FK506) with strong immunosuppressant properties. IC50 Value: 0.55 nM [1] Target: in vitro: When we used either CD4+CD8+ thymocytes or peripheral T cells activated by phorbol ester and ionomycin, the cell surface induction of CD5 was also partially blocked by CsA, FK-520 and rapamycin [2]. Ascomycinalso had a 3-fold lower immunosuppressive potency in a popliteal lymph node hyperplasia assay, resulting in an equivalent therapeutic index consistent with a common mechanistic dependence on calcineurin inhibition [3]. in vivo: In 14-day studies, nephrotoxicity was not induced by continuous i.p. infusion of ascomycin at 10 mg/kg/day or daily oral administration (up to 50 mg/kg/day) in rats on a normal diet, nor by continuous i.v. infusion (up to 6 mg/kg/day) in rats on a low salt diet to enhance susceptibility [3].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.