Chemical Name |
Ro18-5362 |
CAS Number |
101387-97-7 |
Molecular Formula |
C22H25N3O2S |
Molecular Weight |
395.52 |
Introduction of 101387-97-7 :
Ro18-5362 is the less active prodrug of Ro 18-5364. Even at concentrations as high as 0.1 mM Ro 18-5362 fails to affect significantly (H++K+)-ATPase activity and associated proton translocation. In Vitro: Marked differences are seen between Ro 18-5364 (sulfoxide) and Ro18-5362 (sulfide) with regard to inhibitory activity. Even at concentrations as high as 0.1 mM Ro18-5362 fails to affect significantly (H++K+)-ATPase activity and associated proton translocation[1]. The sulfoxide Ro 18-5364, a potential metabolite of the IND Ro18-5362, is a powerful inhibitor of gastric mucosal (H++K+)-ATPase, decreasing enzymatic activity with an apparent Ki of 0.1 μM[2].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.