SC-26196 is a potent, orally active Delta6 desaturase (D6D) inhibitor (IC₅₀=0.2 µM in a rat liver microsomal assay). Antiinflammatory properties^[1]. IC50 & Target: IC50: 0.2 µM (Delta6 desaturase in a rat liver microsomal assay)^[1] In Vitro: SC-26196 (200 nM) inhibits proliferation of peripheral blood mononuclear cells (PBMCs), but Not Jurkat Cells^[2]. In Vivo: SC-26196 ( included in the diet at 0, 0.07, 0.21, or 0.7 mg/kg diet to achieve dosages of 0, 10, 30, and 100 mg/kg per day) causes a decrease in the calculated Δ6-desaturase index in both adipose tissue and liver. Feeding 100 mg SC-26196 per kg BW per day inhibits the Δ6-desaturase enzyme^[3].