CAS No. 155294-62-5, NB-598 (Maleate)

NB-598 (Maleate)

NLT 98%
155294-62-5
DY527276
NB-598 (Maleate)
C31H35NO5S2
565.74

견적 요청

화학 이름 NB-598 (Maleate)
화학 이름 NB-598 (Maleate)
CAS 번호 155294-62-5
MDL 번호 MFCD22665748
분자식 C31H35NO5S2
분자 무게 565.74
Introduction of 155294-62-5 :

NB-598 Maleate is a potent and competitive inhibitor of squalene epoxidase (SE), and suppresses triglyceride biosynthesis through the farnesol pathway. In Vitro: NB-598 (10 μM) causes a 36±7% reduction in total cholesterol level of MIN6 cells. NB-598 causes a significant decrease in cholesterol by 49±2%, 46±7%, and 48±2% from PM, ER, and SG, respectively. NB598 at concentrations up to 10 μM does not affect peak outward KV currents or the voltage dependence of activation but increases current inactivation[1]. NB-598 (10 μM) inhibits the synthesis of sterol and sterol ester from [14C]acetate without affecting the synthesis of other lipids such as phospholipids (PL), free fatty acids (FFA) and triacylglycerol (TG). In the absence of exogenous liposomal cholesterol, NB-598 reduces ACAT activity by 31%. NB-598 reduces ACAT activity by 22% even in the presence of a 600 PM concentration of liposomal cholesterol[2]. NB-598 suppresses the secretion of cholesterol and triacylglycerol from HepG2 cells into the medium[3].

청정 NLT 98%
저장 at 20ºC 2 years
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