CAS No. 1492-18-8, Folinic acid (calcium)

Folinic acid (calcium)

NLT 98%
1492-18-8
DY525549
Folinic acid (calcium)
C20H21CaN7O7
511.50
Leucovorin (calcium);Calcium folinate

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화학 이름 Folinic acid (calcium)
화학 이름 Folinic acid (calcium)
CAS 번호 1492-18-8
MDL 번호 MFCD00006704
분자식 C20H21CaN7O7
분자 무게 511.50
동의어 Leucovorin (calcium);Calcium folinate
Introduction of 1492-18-8 :

Folinic acid calcium (Leucovorin calcium) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity[1]. In Vitro: MTX alone induces a concentration-related increase in % micronucleated binucleated cells (MNBN) and % aberrant cells (Abs). There is a decrease in nuclear division index (NDI) with increase in MTX concentration. Similarly, the mitotic index (MI) also decreases in all concentrations of MTX tested. The addition of Folinic acid at 50 μg/ mL significantly reduces % MNBN (40-68%) and % Abs (36-77%). Inhibition is also seen at 5 μg/ mL Folinic acid (12 to 54% for MNBN and 20 to 61% for Abs) [1]. In Vivo: Folinic acid (7.0 mg/kg; intraperitoneal injection; every second day; for 3 weeks; Balb/c young growing male mice) treatment following methotrexate (MTX) administration appears to reverse this growth inhibition (Chronic administration of MTX induces suppression of skeletal growth in mice)[2].

청정 NLT 98%
저장 at 20ºC 2 years
*위의 정보는 참고 용입니다.

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