CAS No. 1038915-75-1, 2-(4-(Piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide

2-(4-(Piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide

NLT 98%
1038915-75-1
DY503626
2-(4-(Piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide
C19H20N4O
320.39
Niraparib Racemate;MK4827 Racemate;MK 4827 Racemate

견적 요청

화학 이름 2-(4-(Piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide
화학 이름 2-(4-(Piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide
CAS 번호 1038915-75-1
분자식 C19H20N4O
분자 무게 320.39
동의어 Niraparib Racemate;MK4827 Racemate;MK 4827 Racemate
Introduction of 1038915-75-1 :

MK-4827 Racemate is an excellent PARP1 inhibitor with IC50 of 3.2 nM. IC50 & Target: IC50: 3.2 nM (PARP1)[1] In Vitro: MK-4827 R-enantiomer Resolution of MK-4827 Racemate give compounds MK-4827 R-enantiomer and MK-4827 S-enantiomer, both showing excellent inhibition of PARP-1. The MK-4827 R-enantiomer has somewhat lower in vitro metabolic clearance than the MK-4827 S-enantiomer in rat liver microsomes, but MK-4827 S-enantiomer is more potent in cell based assays (PARylation EC50, MK-4827 R-enantiomer=30 nM, MK-4827 S-enantiomer=4.0 nM; BRCA1-HeLa CC50, MK-4827 R-enantiomer=470, MK-4827 S-enantiomer=34 nM). Given this improved potency and similar in vitro turnover in human liver microsomes (HLM Clint, MK-4827 R-enantiomer=4, MK-4827 S-enantiomer=3 μL/min/mgP), MK-4827 S-enantiomer (Niraparib) is focused on[1]. In Vivo: As well as its moderate clearance in rat, MK-4827 S-enantiomer shows good bioavailability (65%) and a high volume of distribution (Vdss=6.9 L/kg), leading to a reasonably long terminal half-life (t1/2=3.4 h)[1].

청정 NLT 98%
저장 at 20ºC 2 years
*위의 정보는 참고 용입니다.

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