MK-2894 sodium salt is a highly potent and selective second generation EP4 antagonist. IC50 value: Target: EP4 MK-2894 exhibits favorable pharmacokinetic profile in a number of preclinical species and potent anti-inflammatory activity in several animal models of pain/inflammation. MK-2894 also shows favorable GI tolerability profile in rats when compared to traditional NSAID indomethacin.