Chemical Name |
4-Methyl-benzhydrylamine resin (200-400 mesh) HCl |
Synonyms |
MBHA resin · HCl;4-CH₃-Ph-CH(NH₂)-Ph-polymer · HCl |
BHA resin turned out to be not sufficiently acid-labile for obtaining peptide amides with sterically hindered C-termini (e.g. Phe, Leu) applying standard cleavage conditions. Introduction of a 4-methyl substituent sufficiently increased the acid-lability of the peptide-resin linkage. Cleavage can be achieved with HF, trifluoromethanesulfonic acid or tetrafluoroboronic acid/thioanisole in TFA using scavengers such as m-cresol and ethanedithiol. This resin has been employed by Pei et al. in the synthesis of quinolinones from β-lactams, and in the conversion of linear peptide amides to cyclic ureas or thioureas.
Purity |
98% Min. |
Storage |
RT |
*The above information is for reference only.