DHPP-resin, i.e. 4-(1',1'-dimethyl-1'-hydroxypropyl)phenoxyacetyl-alanyl-aminomethyl resin, has been developed especially for the synthesis of peptides containing a C-terminal proline. The bulkiness of the linker prevents diketopiperazine formation. As the esterification of Fmoc-Pro-OH (yielding a modified t-butyl ester) is impeded as well, the resin is offered as loaded derivative. Peptides can be cleaved from this resin applying the standard protocols for the cleavage from Wang resin.
Fmoc-Pro-DHPP-resin is an alternative to H-Pro-ClTrt-resin (D-2000) not only if an increased acid stability is required. The resin is more polar than 2-chlorotrityl resin and the Pro residue is more accessible.