Chemical Name |
Fmoc-Asp(OtBu)-(Hmb)Gly-OH |
CAS Number |
502640-94-0 |
MDL Number |
MFCD06656487 |
Molecular Formula |
C33H36N2O9 |
Molecular Weight |
604.65 |
Synonyms |
Fmoc-Asp(OtBu)-N-(2-hydroxy-4-methoxy-Bzl)-Gly-OH |
Aspartimide formation of the highly base-labile Asp-Gly motif during Fmoc-SPPS may be completely suppressed by coupling this Hmb-protected dipeptide derivative. Additionally, Hmb prevents aggregation of the growing peptide chain as efficiently as the incorporation of a pseudoproline moiety. O-Acylation renders the Hmb moiety acid-stable facilitating the purification of peptides prone to form aggregates. The acyl group can be removed with hydrazine hydrate in DMF (cf. Quibell).
Purity |
NLT 98% |
Storage |
-20 ± 5 ºC |
*The above information is for reference only.