(5E,9E,13E)-Teprenone ((5E,9E,13E)-Geranylgeranylacetone) is an isomer of Teprenone with antiulcer activity. (5E,9E,13E)-Teprenone induces transcriptional activation of HSP genes that may increase gastric mucosal defense at conditions of stress^[1]. In Vitro: (5E,9E,13E)-Teprenone might transiently activate the transcription of HSP70 gene^[1].
The heat shock element–binding activity reflects the activation of heat shock factor 1 in response to (5E,9E,13E)-Teprenone^[1].
In Vivo: (5E,9E,13E)-Teprenone induces hat sock proteins accumulations in rat gastric mucosa^[1].