Enmein is isolated from I. serra with immunosuppressive effect^[1]. In Vitro: Enmein shows significant inhibitory effect toward K562 with an IC₅₀ value ranging from 3.2 μg/ml to 8.2 μg/ml^[2].
Enmein (3.13-25 μg/ml; 48 hours) has inhibitory effect on lymphocytes with significant difference within concentration from 6.25 μg/ml to 25 μg/ml^[1].
Enmein (5.5-22 μg/ml; 48 hours) causes the percentage of S stage cells decreased from 19% to 6%, causes the percentage of G2/M stage cells to decrease from 2% to 0.4%^[1].
In Vivo: Enmein (inject to ear; 6.52-13.04 mg/kg; 5 days) inhibits the xylene-induced ear swelling and inhibits IL-2 expression^[1].