Chemical Name |
TDHL |
CAS Number |
37686-84-3 |
MDL Number |
MFCD00242729 |
Molecular Formula |
C20H28N4O |
Molecular Weight |
340.46 |
Synonyms |
Tergurid; Terguride; trans-Dihydrolisuride |
Introduction of 37686-84-3 :
TDHL (Tergurid) is a dopamine receptor agonist with a Kd of 0.39 nM for D2 receptor and an orally available 5-HT-2 receptor antagonist. IC50 & Target: Kd: 0.39 nM (Dopamine D2-receptor)[2], 5-HT2[1] In Vitro: Proliferation and migration of cultured primary human pulmonary artery smooth muscle cells (PASMC) were dose-dependently blocked by TDHL[1].Terguride is found to bind selectively to the pituitary dopamine D2-receptors with a high affinity (Kd=0.39 nM)[2]. In Vivo: TDHL abolished 5-HT-induced pulmonary vasoconstriction. Chronic terguride treatment prevented dose-dependently the development and progression of MCT-induced PAH in rats[1]. In reserpinized rats, terguride at 0.03 mg/kg, p.o. significantly reduces the serum prolactin (PRL) level. In rats bearing estrogen-induced pituitary prolactinoma, chronic terguride induces shrinkage of the prolactinoma as well as reduction of the high serum PRL level. In lactating rats, terguride (1.0 mg/kg, s.c.) reduces milk production in the mammary gland[2].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.