TCS-OX2-29
| Chemical Name | TCS-OX2-29 |
|---|---|
| CAS Number | 372523-75-6 |
| MDL Number | MFCD12828766 |
| Molecular Formula | C23H32ClN3O3 |
| Molecular Weight | 433.97 |
Introduction of 372523-75-6 :
TCS-OX2-29 is a potent, high affinities and selective orexin-2 receptor (OX2R) antagonist with an IC50 value of 40 nM and a pKI value of 7.5. TCS-OX2-29 displays ~250-fold selectivity for OX2 over OX1[1][2]. IC50 & Target: IC50: 40 nM (OX2R)[1]; pKi: 7.5 (OX2R)[2] In Vitro: TCS-OX2-29 inhibits orexin A induced IP3 accumulation and ERK1/2 phosphorylation in CHO cells transfected with the OX2 receptor[2]. In Vivo: TCS-OX2-29 (5-10 mg/kg; intraperitoneal injection; adult male NMRI mice) treatment suppresses conditioned place preference (CPP) acquisition and expression in both naïve and dependent mice significantly[3].
| Purity | NLT 98% |
|---|---|
| Storage | at 20ºC 2 years |
*The above information is for reference only.