Chemical Name |
(±)-Ibipinabant |
CAS Number |
362519-49-1 |
MDL Number |
MFCD12912330 |
Molecular Formula |
C23H20Cl2N4O2S |
Molecular Weight |
487.40 |
Synonyms |
(±)-SLV319;(±)-BMS6462 |
Introduction of 362519-49-1 :
(±)-Ibipinabant ((±)-SLV319) is the racemate of SLV319. (±)-Ibipinabant ((±)-SLV319) is a potent and selective cannabinoid-1 (CB-1) receptor antagonist with an IC50 of 22 nM. IC50 & Target: IC50: 22 nM (CB-1)[1]; Ki: 7.8 nM (CB-1)[2] In Vitro: Cannabinoid receptor 1 (CB1R) antagonists appear to be promising drugs for the treatment of obesity, however, serious side effects have hampered their clinical application. Ibipinabant is a new, potent [Ki (CB1)=7.8 nM] and selective [Ki (CB2)=7.943 nM] CB1 antagonist [pA2 for arachidonic acid release in CHO cells=9.9] with in vitro pharmacological characteristics similar to rimonabant including inverse agonism and brain penetrance[3]. In Vivo: (±)-Ibipinabant ((±)-SLV319) (3 mg/kg) reduces unfasted glucose to a significantly greater degree than rimonabant at the same dose on days 17, 28 and 38. Chronic treatment with (±)-Ibipinabant ((±)-SLV319) significantly attenuates the progression of diabetes in ZDF rats, blunting the increase in blood glucose and HbA1c over time. Ibipinabant also reduces the hyperinsulinemia apparent at 6-8 weeks of age and attenuates the dramatic reduction in insulin levels observed 1-2 weeks later[3].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.