Chemical Name |
SB-423557 |
CAS Number |
351490-26-1 |
MDL Number |
MFCD22665716 |
Molecular Formula |
C28H36N2O4 |
Molecular Weight |
464.60 |
Introduction of 351490-26-1 :
SB-423557 is an orally active calcium-sensing receptor (CaR) antagonist (IC50=520 nM), precursor of SB-423562 (IC50=73 nM). SB-423557 is well tolerated in human and increases plasma concentrations of exogenous parathyroid hormone (PTH) and stimulates bone formation[1]. IC50 & Target: IC50: 520 nM (Calcium-sensing receptor)[1] In Vivo: SB-423557 (oral administration; 10, 30 or 100 μM/kg; once daily; 12 weeks) elicits transient increases in plasma concentrations of PTH, resulting in increased bone mass and strength in both vertebrae and long bones compared to that of OVX controls[1].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.