Chemical Name |
TS-011 |
CAS Number |
339071-18-0 |
MDL Number |
MFCD21603938 |
Molecular Formula |
C11H14ClN3O2 |
Molecular Weight |
255.70 |
Introduction of 339071-18-0 :
TS-011 is a selective inhibitor of 20-Hydroxyeicosatetraenoic acid synthesis. In Vivo: TS-011 is a selective inhibitor of 20-Hydroxyeicosatetraenoic acidsynthesis. TS-011 at a dose of 0.3 mg/kg inhibits the reduction in the blood flow velocities at 1 and 7 h after reperfusion (P<0.001). In addition, TS-011 inhibits the increase in the blood flow velocity at 24 h after reperfusion (P<0.01). TS-011 protects the microvascular perfusion area from the loss observed in vehicle-treated mice. TS-011, at a dose of 0.3 mg/kg, also reduces the infarct volume by almost 40% (P<0.05)[1]. In 9 dogs with delayed vasospasm, acute blockade of the synthesis of 20-HETE with TS-011 (1 mg/kg IV) significantly increases the diameter of the basilar artery by 39%[2].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.