Silychristin
| Chemical Name | Silychristin |
|---|---|
| CAS Number | 33889-69-9 |
| MDL Number | MFCD00883715 |
| Molecular Formula | C25H22O10 |
| Molecular Weight | 482.44 |
Introduction of 33889-69-9 :
Silychristin is an abundant flavonolignan present in the fruits of Silybum marianum, with antioxidant properties. Silychristin is a potent inhibitor of the thyroid hormone transporter MCT8, and elicits a strong inhibition of T3 uptake with an IC50 of 110 nM[1][2]. IC50 & Target: MCT8[2] In Vitro: Silychristin exhibits a strong inhibition of MCT8-mediated T3 uptake with an IC50 of 110 nM in MCT8 overexpressing MDCK1-cells[2].
Silychristin causes no cytotoxic for fibroblasts[3].
Silychristin (6.5-75 μM; 24 hours) diminishes UVA toxicity and reduces ROS generation, and the protective effect is dose-dependent[3].
Silychristin (12.5μM, 25μM) reduces the metalloproteinase-1 (MMP-1) level in cells[3].
| Purity | NLT 98% |
|---|---|
| Storage | at 20ºC 2 years |
*The above information is for reference only.