Chemical Name |
ICA |
CAS Number |
3374-88-7 |
MDL Number |
MFCD00005611 |
Molecular Formula |
C9H7NO2 |
Molecular Weight |
161.16 |
Synonyms |
N-[4-(2-Pyridinyl)-2-thiazolyl]-2-pyridinamine |
Introduction of 3374-88-7 :
ICA (N-(pyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine) is a SK channel inhibitor that has antileishmanial activity with an IC50 of 2.1 µM. IC50 & Target: IC50: 2.1 µM (Antileishmanial)[1] In Vitro: The SK channel inhibitor ICA exhibits antiarrhythmic effects. ICA prevents electrically induced runs of atrial fibrillation in the isolated right atrium and induces atrial postrepolarization refractoriness and depolarizes resting membrane potential. ICA at 1 to 10 μM slows conduction velocity. At increased pacing frequencies, SK channel inhibition by ICA (10-30 μM) demonstrates prominent depression of other sodium channel-dependent parameters[2].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.