Chemical Name |
Hypophyllanthin |
CAS Number |
33676-00-5 |
MDL Number |
MFCD03424459 |
Molecular Formula |
C24H30O7 |
Molecular Weight |
430.49 |
Introduction of 33676-00-5 :
Hypophyllanthin is a major lignan in Phyllanthus spp, with strong anti-inflammatory activity. Hypophyllanthin directly inhibits P-glycoprotein (P-gp) activity and did not interfere with multidrug resistance protein 2 (MRP2) activity[1][2]. IC50 & Target: P-gp[2] In Vitro: Hypophyllanthin down-regulates COX-2, TNF-α, and IL-1β gene expressions in U937 macrophages by interfering with the activation of NF-κB, MAPKs, and Akt[1].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.