Chemical Name |
IQ 1 |
CAS Number |
331001-62-8 |
MDL Number |
MFCD00354369 |
Molecular Formula |
C21H22N4O2 |
Molecular Weight |
362.42 |
Introduction of 331001-62-8 :
IQ 1 has many functions such as decreasing Wnt-stimulated phosphorylation, maintaining the pluripotency of murine ESCs, preventing PP2A/Nkd interaction and so on. IQ 1 maintains the pluripotency of murine ESCs in long-term culture in a Wnt-dependent manner. IQ 1 decreased Wnt-stimulated phosphorylation of p300 at Ser-89.IQ-1 binds to serine/threonine phosphatase PP2A and prevents PP2A/Nkd interaction.The binding of IQ 1 to PR72/130 leads to decreased phosphorylation of the coactivator protein p300 at Ser-89. IQ 1 thereby diminishes the β-catenin/p300 interaction and prevents β-catenin coactivator switching from CBP to p300.
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.