Chemical Name |
Lirimilast |
CAS Number |
329306-27-6 |
MDL Number |
MFCD09837901 |
Molecular Formula |
C17H12Cl2N2O6S |
Molecular Weight |
443.26 |
Synonyms |
BAY 19-8004 |
Introduction of 329306-27-6 :
Lirimilast (BAY 19-8004) is a potent, selective and orally active phosphodiesterase-4 (PDE4) inhibitor with an IC50 value of 49 nM. Lirimilast can be used for the treatment of asthma or chronic obstructive pulmonary disease (COPD). Lirimilast has potently anti-inflammatory properties[1][2]. In Vitro: In PDE4 assays Lirimilast (BAY 19-8004) is reported to be 5-fold more potent than Cilomilast and equipotent with CDP-840 using freshly prepared PDE4 from human PMNL[1]. In Vivo: Since Lirimilast (BAY 19-8004) is orally active in the guinea-pig at 3 mg/kg and, more critically, in primates at 0.1 mg/kg/day it appears to have a good therapeutic ratio. In addition Lirimilast is found to be 3-fold more potent than Cilomilast when compared in a rat model of lung neutrophilic inflammation[2].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.