Chemical Name |
5-Azacytidine |
CAS Number |
320-67-2 |
Molecular Formula |
C8H12N4O5 |
Molecular Weight |
244.20 |
Synonyms |
Azacitidine;5-AzaC;Ladakamycin |
Introduction of 320-67-2 :
5-Azacytidine (Azacitidine; 5-AzaC; Ladakamycin) is a nucleoside analogue of cytidine that specifically inhibits DNA methylation. 5-Azacytidine is incorporated into DNA to covalently trap DNA methyltransferases and contributes to reverse epigenetic changes[1][2]. 5-Azacytidine induces cell autophagy[4]. IC50 & Target: IC50: DNA methyltransferases; autophagy[1] In Vitro: Unmethylated CpG islands associated with a variety of genes become partially or fully methylated in tumors and can be reactivated by 5-Azacytidine[1]. 5-Azacytidine acts as weak inducers of erythroid differentiation of Friend erythroleukemia cells in the same concentration range where they affect DNA methyltransferase activity[2]. 5-Azacytidine inhibits L1210 cells with ID50 and ID90 values of 0.019 and circa 0.15 μg/mL, respectively[3]. In Vivo: TdR-3H incorporation is significantly inhibited when the animals are exposed to 5-Azacitidine (100 mg/kg, i.p.) for 2 hr or longer[3].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.