Chemical Name |
Palifosfamide |
CAS Number |
31645-39-3 |
MDL Number |
MFCD01705455 |
Molecular Formula |
C4H11Cl2N2O2P |
Molecular Weight |
221.02 |
Synonyms |
Isophosphoramide mustard;IPM;ZIO-201 |
Introduction of 31645-39-3 :
Palifosfamide is a novel DNA alkylator and the active metabolite of ifosfamide, with antitumor activity. In Vitro: Palifosfamide lysine (ZIO-201) is a stable form of palifosfamide. Palifosfamide lysine has broad activity in sarcoma lines in vitro. The IC50 ranges from 2.25 ro 6.75 μM for most cell lines except OS222 (IC50=31.5 μM)[1]. In Vivo: Tumor growth inhibition is seen in both OS31 and OS33 xenografts and the RMS xenograft resulting in a significant difference in event-free survival between the control and the treated groups. Differential gene expression of ALDH3A1 but not ALDH1A1 is noted in the OS31 xenograft[1]. Stabilized palifosfamide administered to mice suppresses MX-1 tumor growth by greater than 80% with 17% complete antitumor responses. Oral bioavailability in rats is 48-73% of parenteral administration, and antitumor activity in mice is equivalent by both routes. Treatment with palifosfamide-tris combined with docetaxelor doxorubicin at optimal regimens results in complete tumor regression in 62-75% of mice[2].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.