Chemical Name |
Aristolochic acid A |
CAS Number |
313-67-7 |
MDL Number |
MFCD00004996 |
Molecular Formula |
C17H11NO7 |
Molecular Weight |
341.27 |
Synonyms |
Aristolochic acid I;TR 1736 |
Introduction of 313-67-7 :
Aristolochic acid A (Aristolochic acid I; TR 1736) is the main component of plant extract Aristolochic acids, which are found in various herbal plants of genus Aristolochia and Asarum. Aristolochic acid A significantly reduces both activator protein 1 (AP-1) and NF-κB activities. Aristolochic acid A reduces BLCAP gene expression in human cell lines[1]. In Vitro: Aristolochic acid A (150, 200 μM, 24 hours) inhibits the cell viabilities of kidney cells HEK293 and HK-2[1].
Aristolochic acid A (100, 200 μM, 24 hours) causes a concentration-dependent decrease in bladder cancer-associated protein (BLCAP) mRNA levels in kidney cells (HEK 293 and HK-2) , and bladder cancer cell line (HT-1376)[1].
Aristolochic acid A (100, 200 μM, 24 hours) weakens the BLCAP protein signals in a dose-dependent manner in both HEK293 and HT-1376 cells[1].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.