Fargesin is a bioactive neolignan isolated from magnolia plants，with antihypertensive and anti-inflammatory effects^[1][2][3]. In Vitro: Fargesin exhibits anti-inflammation effects on THP-1 cells via suppression of PKC pathway including downstream JNK, nuclear factors AP-1 and NF-ĸB^[3].
Fargesin as a potential β₁ adrenergic receptor antagonist protects the hearts against ischemia/reperfusion injury in rats via attenuating oxidative stress and apoptosis^[4].
In Vivo: Fargesin has antihypertensive effect in 2K1C hypertensive rats via inhibiting oxidative stress and promoting NO release^[1].