Chemical Name |
AEBSF (hydrochloride) |
CAS Number |
30827-99-7 |
MDL Number |
MFCD00132962 |
Molecular Formula |
C8H11ClFNO2S |
Molecular Weight |
239.69 |
Introduction of 30827-99-7 :
AEBSF hydrochloride is an irreversible inhibitor of serine proteases, such as chymotrypsin, kallikrein, plasmin, thrombin, and trypsin. In Vitro: AEBSF inhibits the constitutive production of Aβ by directly inhibiting β-secretase in five different human cell lines, both neural and nonneural[1]. AEBSF, as a serine protease inhibitor, inhibits the lysis of leukemic cells by human macrophages without inhibiting macrophage secretion of TNF-α and IL-1β[2]. AEBSF also disturbs the growth of blastocysts on endometrial cells and inhibit the adhesion of HeLa cells on HUVECs by altering the protein secretion pattern[4]. In Vivo: AEBSF (76.8 mg/kg daily, i.p.) results in prolongation of the survival of mice that have been given a lethal T. gondii infection[3]. AEBSF also reduces airway response and underlying inflammation in cockroach allergen-induced murine model[4].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.