Chemical Name |
Clinofibrate |
CAS Number |
30299-08-2 |
MDL Number |
MFCD00865769 |
Molecular Formula |
C28H36O6 |
Molecular Weight |
468.58 |
Synonyms |
S-8527 |
Introduction of 30299-08-2 :
Clinofibrate (S-8527) is a hypelipidemic agent and a HMG-CoA reductase inhibitor. In Vivo: Clinofibrate administration (50 and 100 mg/kg/day, p.o.) significantly inhibits the increase in plasma fibrinogen level as well as serum- and VLDL-LDL-lipids[1]. Clinofibrate significantly decreases the high plasma cholesterol level of atherosclerotic rats, which is 823±256 mg/dl, or about ten times that of control rats (85±11 mg/dl). On treatment with clinofibrate, the cholesterol level is reduced most in the very low density lipoprotein (VLDL) fraction[2]. In rats which are refed either a fat-free diet or a 5% fat diet after a 2-day fast. clinofibrate at 30 mg/kg results in reductions of serum and liver triglyceride levels[3]. Oral ingestion of S-8527 to normal rats for 7 days lowers serum triglycerides and cholesterol by about 27% at 1 mg/kg and 20% at 3 mg/kg, respectively. S-8527 at 3 mg/kg decreases liver triglyceride concentration by about 20%[4].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.