Chemical Name |
25,26-Dihydroxyvitamin D3 |
CAS Number |
29261-12-9 |
MDL Number |
MFCD03787937 |
Molecular Formula |
C27H44O3 |
Molecular Weight |
416.64 |
Synonyms |
25,26-Dihydroxycholecalciferol |
Introduction of 29261-12-9 :
25,26-Dihydroxyvitamin D3(25,26-dihydroxycholecalciferol) is a metabolite of vitamin D3 with intestinal calcium transport activity. IC50 value: Target: VD metabolite The biological activity of synthetic 24,25 and 25,26 diOHD3 was studied in vitamin D-deficient rats. The purpose of this study was to investigate the influence of small doses of both metabolites (0.125-0.250 mug) upon intestinal calcium transport and bone calcium mobilization. Both metabolites were able to increase calcium absorption in rats maintained on a calcium-deficient diet, but failed to do it in rats on a normal calcium diet. Bilateral nephrectomy suppressed this effect. The "bone calcium mobilization" of both derivatives was measured in vitamin D and calcium- or phosphorus-deprived rats after one intravenous dose. When serum calcium was initially low, 24,25 and 25,26 diOHD3 increased serum calcium moderately, but the increment was only significant with 24,25 diOHD3.
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.