Chemical Name |
Befetupitant |
CAS Number |
290296-68-3 |
MDL Number |
MFCD13152376 |
Molecular Formula |
C29H29F6N3O2 |
Molecular Weight |
565.55 |
Synonyms |
Ro67-5930 |
Introduction of 290296-68-3 :
Befetupitant is a high-affinity, nonpeptide, competitive tachykinin 1 receptor (NK1R) antagonist. IC50 & Target: NK1R[1] In Vivo: Befetupitant, a different, highly selective NK1R antagonist, is tested in the alkali burn model. Topical application of Befetupitant for 4 days is effective (P<0.05) in reducing hemangiogenesis and lymphangiogenesis at both concentrations (0.4 and 1.6 mg/mL). Befetupitant and its vehicle DMSO, however, induced corneal opacity even in healthy controls, as observed at slit-lamp examination. Moreover, fluorescein and hematoxylin-eosin staining showed epithelial damage and inflammatory cellular infiltration in the stroma, respectively, confirming DMSO toxicity. Topical application of Befetupitant reduces corneal neovascularization (CNV) in the alkali burn model but is toxic owing to the vehicle (DMSO); hence, Befetupitant is not tested in the suture model[1].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.