Chemical Name |
Benzamil |
CAS Number |
2898-76-2 |
MDL Number |
MFCD05237236 |
Molecular Formula |
C13H14ClN7O |
Molecular Weight |
319.75 |
Synonyms |
Benzylamiloride |
Introduction of 2898-76-2 :
Benzamil (Benzylamiloride), an Amiloride analogue, is a Na+/Ca2+ exchanger (NCX) inhibitor (IC50~100 nM). Benzamil also is a non-selective Deg/epithelial sodium channels (ENaC) blocker, and can potentiate myogenic vasoconstriction. Benzamil inhibits TRPP3-mediated Ca2+-activated currents, with an IC50 of 1.1 μM[1][2][3]. In Vitro: Benzamil (Benzylamiloride) inhibits neuronal and heterologously expressed small conductance Ca2+-activated K2+ channels[4]. In Vivo: Benzamil (Benzylamiloride) (0.7 mg/kg/day; s.c.) treated stroke-prone spontaneously hypertensive rats (SHRSP) survived, on average, until 16.1 weeks of age in SHRSP rats[5].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.