Chemical Name |
Senicapoc |
CAS Number |
289656-45-7 |
MDL Number |
MFCD09027349 |
Molecular Formula |
C20H15F2NO |
Molecular Weight |
323.34 |
Synonyms |
ICA-17043 |
Introduction of 289656-45-7 :
Senicapoc (ICA-17043) is a potent and selective Gardos channel (Ca2+-activated K+ channel; KCa3.1) blocker with an IC50 of 11 nM. Senicapoc blocks Ca2+-induced rubidium flux from human RBCs with an IC50 value of 11 nM and inhibits RBC dehydration with IC50 of 30 nM[1]. IC50 & Target: IC50: 11 nM (Gardos channel)[1] In Vitro: ICA-17043 is shown to block the Gardos channel of mouse (C57 Black) RBCs with an IC50 of 50±6 nM. ICA-17043 blocks this increase in cellular hemoglobin concentration in human RBCs in a concentration-dependent fashion[1]. In Vivo: ICA-17043 (10 mg/kg, p.o.) administration produces a significant decrease in Gardos channel activity measured at day 11 and 21 and is associated with a corresponding increase in red cell K+ content without changes in Na+ content. ICA-17043 (10 mg/kg, twice a day) induces a significant increase in Hct after 11 days of dosing in the SAD mouse[1]. Senicapoc (30 mg/kg, p.o.) reduces airway hyperresponsiveness, eosinophil numbers in bronchoalveolar lavage taken 48 hours post-allergen challenge, and vascular remodelling in the sheep[2].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.