Chemical Name |
DHMEQ (racemate) |
CAS Number |
287194-38-1 |
MDL Number |
MFCD15143434 |
Molecular Formula |
C13H11NO5 |
Molecular Weight |
261.23 |
Synonyms |
rel-DHMEQ |
Introduction of 287194-38-1 :
DHMEQ racemate is a NF-κB inhibitor. DHMEQ racemate is less active than (-)-DHMEQ. IC50 & Target: NF-κB[1] In Vitro: DHMEQ racemate (DHM3EQ) and (-)-DHMEQ (DHM2EQ) inhibits TNF-a-induced NF-kB activation. (-)-DHMEQ is more potent and less toxic than DHMEQ racemate[1]. In Vivo: The antiarthritic effects of (-)-DHMEQ (DHM2EQ) and DHMEQ racemate (DHM3EQ) are examined on type-II collagen-induced arthritis in DBA1/J mice. This animal model is widely used for evaluation of antirheumatic drugs because of its pathological similarities to human rheumatoid arthritis. The arthritis is elicited and scored. (-)-DHMEQ markedly inhibits type-II-collagen-induced arthritis in mice, whereas DHMEQ racemate tends to only slightly inhibit it[1].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.