Chemical Name |
Transcrocetin |
CAS Number |
27876-94-4 |
MDL Number |
MFCD00017359 |
Molecular Formula |
C20H24O4 |
Molecular Weight |
328.40 |
Synonyms |
trans-Crocetin |
Introduction of 27876-94-4 :
Transcrocetin (trans-Crocetin), extracted from saffron (Crocus sativus L.), acts as an NMDA receptor antagonist with high affinity[1]. Transcrocetin (trans-Crocetin) is capable of crossing the blood-brain barrier and reach the central nervous system (CNS)[2]. IC50 & Target: NMDA receptor[1] In Vitro: Transcrocetin (trans-Crocetin), a saffron metabolite originating from the crocin apocarotenoids, has been shown to exert strong NMDA receptor affinity and is thought to be responsible for the CNS activity of saffron.To ensure unchanged viability of Caco-2 cells throughout the transport experiments, cellular mitochondrial dehydrogenase activity of Caco-2 cells is measured by MTT assay after a 24 h incubation period with the test compounds: Hydroalcoholic saffron extract saffron extract (SE, 0.5-1 mg/mL) and crocin-1 (250-1000 µM) reveal no negative significant changes in cellular viability. Transcrocetin at 10 µM level does not change viability while higher concentrations (40-160 µM) reduces significantly cellular viability[1].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.